Transcriptional reprogramming under vancomycin pressure in Staphylococcus aureus
نویسندگان
چکیده
The World Health Organization (WHO) has defined Vancomycin intermediate Staphylococcus aureus (VISA) and resistant (VRSA) as high priority pathogens. VISA VRSA are produced by different mechanisms, hence cannot convert to VRSA. Consequently, upon vancomycin treatment of VSSA isolates, there can be emergence but not its conversion But we observed that when (MIC ≤2 µg/mL) lacking vanA or vanB genes, grown under stress for 60 days, 4 out 8 isolates get converted = 4-8 µg/mL), 1 ≥16 µg/mL). Further, the isolate had a MIC was 8-fold higher than sensitive counterpart. Hence, been interpreted heteroresistant isolate. To dissect molecular underpinning this transient resistance pattern, analyzed gene expression profile these publicly available datasets. pbp2 consistently upregulated in all except Pathway analysis revealed upregulation peptidoglycan biosynthesis isolates. However, distinct transcriptional (with recR, ureC atl) suggests potential role increased mutation due SOS response biofilm formation phenotype.
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ژورنال
عنوان ژورنال: Indian Journal of Experimental Biology
سال: 2023
ISSN: ['0019-5189']
DOI: https://doi.org/10.56042/ijeb.v61i07.2211